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Matthews, T

This hormonal signal triggers intracellular signaling cascades through cyclic AMP (cAMP), protein kinase A (PKA) and subsequent transcription factors that act together to regulate steroidogenic gene expression ( Figure 1 odern research suggests that metabolic regulators such as AMP-activated protein kinase (AMPK) and transcriptional modulators like peroxisome proliferator-activated receptor gamma (PPAR) orchestrate steroidogenic gene expression through their interactions with hormonal signals (LH, PGF2) and epigenetic modifiers such as enhancer of zeste homolog 2 (EZH2) ( Recent empirical evidence suggests that epigenetic processes, such as DNA methylation, histone modifications, and non-coding RNAs represent important control layers in the biology of the corpus luteum ( Non-coding RNA elements, especially microRNAs (miRNAs) tightly regulate the principal luteal transcriptome

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When saliva production declines, gum tissue becomes more susceptible to inflammation, bacterial plaque accumulation, and early-stage gum disease (gingivitis)