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Oral formulations of both compounds typically clear faster than injectable versions because they bypass the subcutaneous depot effect that extends release

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Experimental evidence demonstrated that treatment with (Ex-4)2-Fc promotes the conversion of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages, leading to increased expression of anti-inflammatory factors and significant reductions in pro-inflammatory markers

More data are needed to clarify the effects of GLP-1RAs on the incidence of OA, RA, PsA and axSpA, as well as on disease activity and progression in these conditions