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Application Aside from their benefits for the treatment of type 2 diabetes and obesity, GLP-1 based drugs are beginning to be approved for the treatment of other conditions

Many thanks also go to Bernard Thorens, Richard DiMarchi, Lotte Knudsen, John Eng, Jean-Pierre Raufman, Richard Goodman, Catherine rskov, Matthias Tschp, Daniel Drucker, Jesper Lau and Fred Cowan for their comments on various sections and providing permission to use their photos

In this context, murine studies have shown that sweet taste receptors (TAS1R2 and TAS1R3) are predominantly expressed in the hypothalamus and brainstem, whereas bitter receptors (TAS2R116, TAS2R118, TAS2R138, TAS2R104) are mainly expressed in the arcuate nucleus, ventromedial hypothalamus, dorsomedial hypothalamus, and nucleus of the solitary tract (120, 121)

Updated March 12, 2026