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A sub-study of the PREDIMED trial examining changes in inflammatory markers after 3 years of MedDiet intervention found reduced plasma levels of several inflammatory cytokines (IL-1, IL-6, IL-8, TNF-, IFN-, hs-CRP, MCP-1, MIP-1, RANTES, and ENA78), but these did not reflect at the gene level (60)

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After examining about 2 million patients with type 2 diabetes or obesity, the research team - led by biomedical informatics professor Rong Xu - found no evidence to support concerns by the European Medicines Agency (EMA) that semaglutide may cause suicidal ideations