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The cardiovascular protection observed in these trials likely results from multiple mechanisms: weight loss itself, direct effects on inflammation, improved blood vessel function, and favorable changes in lipid levels all working together to reduce disease risk

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Whilst heartburn or reflux were not consistently itemised as standalone symptoms in trial reporting, nausea, vomiting, and upper abdominal discomfort symptoms that frequently co-exist with reflux were consistently noted

NICE recommends checking lipid profiles 3 months after initiating or changing lipid-lowering therapy, then annually once stable