& McNamara, C
In terms of frequency, short-term high-frequency administration (e.g., once daily for 3 consecutive days) enables rapid initiation of therapeutic efficacy, whereas long-term administration once weekly or once every 2 weeks is sufficient to maintain stable improvements, which aligns with clinical practice requirements (Klinger et al., 2021)
2 Methodology This review was conducted through a literature search in PubMed, Scopus, Web of Science and Google Scholar, using combinations of keywords such as Parkinsons disease, -synuclein aggregation, sirtuins, insulin signaling, GLP-1 and incretin mimetics phytomolecules, neuroprotection, and therapeutics. The search covered publications from 2010 to January 2026
Effects of exercise on mitochondrial content and function in aging human skeletal muscle