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Comparison of both CCR8 structures indicate that in the Fab1-bound structure, the ECLs 1-2 and the intracellular loops (ICLs) 1-2 are well resolved, while the N-terminus, ECL3 and ICL3 are disordered (Supplementary Fig

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Furthermore, GDF15 has been implicated in disorders associated with central sensitization, highlighting its relevance to FM pathophysiology 11

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