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During the 26 week randomized treatment period, the percentage of patients who discontinued due to ineffective therapy was 11.2% in the group randomized to continued treatment with liraglutide injection 1.8 mg and metformin and 1.2% in the group randomized to add-on therapy with insulin detemir

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via the activation of Nrf2 pathway and Sirtuin-3-FoxO3a pathway in AKI and CKD models (Xu et al., 2012