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No heavy, greasy, or sugary meals late at night

We are grateful to the UK Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/P020194/1)

Those craving nicotine daily dropped from 14.1% (55 participants) to 4.4% (17 participants), while those craving nicotine multiple times per day decreased from 18.2% (71 participants) to 5.1% (20 participants)

In brief, FLS were incubated with 5 M Fluo-4-AM for 30 min, and the intracellular influx of calcium was observed under an LSM700 laser scanning confocal microscope (Zeiss, Germany) at a 1/s frequency