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However, Dihexa remains entirely preclinical, and its foundational research has faced serious integrity concerns including an expression of concern and a retraction on key papers

Signal Pathway Activation: When MT2 binds to the MC1R receptor, it initiates an intracellular signaling cascade, increasing cyclic adenosine monophosphate (cAMP) levels and activating protein kinase A (PKA)

The median AMSTAR 2 score for the included meta-analyses was 23 (range: 732