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Understanding these potential mechanisms helps clinicians counsel patients appropriately and distinguish between expected treatment effects and concerning adverse reactions

For the moment, a certain association rate (K on ) is required to ensure ligand binding to receptors in blood flow and to compete with endogenous incretins to decrease internalization

In the Phase 2 clinical trial, participants generally met the following criteria: Body mass index (BMI) of 27 kg/m or above with at least one weight-related comorbidity (such as hypertension, dyslipidaemia, or obstructive sleep apnoea), or a BMI of 30 kg/m or above without comorbidities

The clinical trials used a structured escalation schedule designed to give the gastrointestinal system time to adapt to each new level of receptor activation