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By balancing enhanced receptor affinity with safety considerations (e.g., immunogenicity, DPP4 digestion), the work highlights opportunities to refine therapeutic outcomes for metabolic disorders
GLP-1 medications such as semaglutide, tirzepatide, Wegovy, Ozempic, Zepbound, and Mounjaro require evaluation and a prescription from a licensed clinician
Clinical trials demonstrate average weight reductions of 15-20% body weight when coupled with lifestyle modifications, positioning it as a front-runner in weight loss treatments
Dysfunctional mitochondria produce excessive reactive oxygen species (ROS), leading to increased tumour proliferation, invasion, and angiogenesis [72]
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