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Only three cases had documented concurrent thyroid diseases, such as Hashimotos thyroiditis, indicating that thyroid dysfunction postvaccination may primarily arise as a new autoimmune phenomenon

Genetic polymorphisms in NAT2 (N-acetyltransferase 2), TPMT (thiopurine methyltransferase), and glutathione S-transferase genes create phenotypic differences

Human studies have produced mixed results