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These include the POMC-derived peptides released by neighbouring keratinocytes and the neuropeptide calcitonin gene-related peptide, substance P, and neuropeptide Y released from intramucosal free nerve endings, which are in close contact with melanocytes in the basal cell layer of the epithelium

Besides their GPCR nature and the associated implications for drug discovery, one of the most interesting aspects of the melanocortin system ( Figure 2 ) that makes it very attractive for the development of new therapies is the remarkable functional specialization of the MC receptors, controlling multiple and diverse processes around the body, including skin pigmentation and DNA repair, appetite regulation, blood pressure, production of cortisol, regulation of glands secretions, and immune responses, among others (159)

As a culture, one of our greatest challenges is the over-provision of energy (read: food) to our bodies

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