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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

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Acetyl coenzyme A (Acetyl-CoA), produced through the metabolism of glucose, fatty acids, and amino acids [7], is utilized in cholesterol synthesis, a process regulated by SREBP-2 through the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis