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Treating cells with cumene hydroperoxide was shown to enhance eryptosis, whereas the antioxidant NAC mitigated this process by enhancing RBC deformability and reducing levels of ROS, calcium, and PS exposure, and demonstrated that oxidative stress plays a crucial role in eryptosis, with pro-oxidants promoting and antioxidants limiting eryptotic processes [413]

revealed that in liver cancer, hypoxia activates MAT2A expression through hypoxia-inducible factor-1, resulting in increased MAT II enzyme activity and reduced SAM production, which then induces genomic DNA demethylation

[6] Hu S, Rayman MP

Evaluation of oxidative stress level: total antioxidant capacity, total oxidant status and glutathione activity in patients with COVID-19