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While the size difference between tripeptides and heptapeptides (e.g., CyRL-QN15) may appear modest in terms of amino acid count, this difference may significantly influence their structural complexity, biological activity, and interaction with cellular targets

But the clinical evidence base is thinner than the marketing suggests, and critical questions about skin penetration, optimal formulation, and long-term outcomes remain unanswered

Jian Li, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Shokolenko IN, Alexeyev MF