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Findings: RCTSTEP-HFpEF DM trial - Semaglutide vs Placebo in Obese Diabetics with HFpEF, NEJM (2024) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=616 | length = 52 weeks) in obese type 2 diabetics (BMI 30) with HFpEF Treatment: Semaglutide titrated to 2.4 mg once weekly vs Placebo Primary outcome: Change from baseline in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS

qRT-PCR was carried out on a Hongshi SLAN-96P instrument after adding primers and TB Green Premix Ex Taq (2X) (RR420L, Takara, Japan) to the 10-fold diluted cDNA

What might be the implications of semaglutides renal protective benefits and its ability to reduce liver fat content for patients with multiple metabolic disorders, such as chronic kidney disease and non-alcoholic steatohepatitis