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We noted, in the CY 2026 OPPS/ASC proposed rule, that based on the description provided by the applicant, that the aprevo Cervical ACDF System is a personalized interbody cage that is implanted using an anterior surgical approach, and therefore, could be appropriately described by C1831

Common Side Effects Experienced by some users Water retention and swelling Fluid retention in hands, feet, and ankles is one of the most common early side effects

First, the unique physicochemical properties of nanomaterials (e.g., size, shape, surface charge) may result in biological behaviors that differ significantly from traditional drugs, necessitating a reassessment of their safety, efficacy, and toxicological characteristics by regulatory agencies

Sources Pickart L, Vasquez-Soltero JM, Margolina A