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[4] [11] This mechanism becomes clinically relevant when treating pernicious anaemia or intrinsic factor deficiency with high-dose oral supplementation

Abbreviations ACP1 - acid phosphatase CAT - catalase FMN - flavin mononucleotide GPX - glutathione peroxidase GSH - plasma reduced glutathione GSSG - oxidised glutathione MHR - methemoglobin reductase SOD - Zn/Cu superoxide dismutase TMR - transmembrane reductase of ferricyanide Methemoglobin reductase (MHR) is an erythrocyte cytosolic system responsible for reactivating haemoglobin's ability to transport oxygen after it has been converted into methemoglobin by reactive oxygen species (Board & Pidcock, 1981

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When combined with GHRH, the result was a striking synergistic response of 3771.5 plus or minus 399.6, roughly 2.6 times higher than GHRP-6 alone