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Because full-dose GLP-1 therapy can be difficult to tolerate long term, microdosing is being explored as a way to maintain consistent neurotrophic signaling over years rather than monthspotentially supporting brain resilience, mitochondrial health, and cognitive longevity

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Prior literature, particularly one other case report, has raised the possibility of an association between GLP-1 agonist use and the development of non-alcoholic Wernickes encephalopathy (NAWE), like our patient [14]