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Mechanisms : Its role extends to antioxidant activity, promoting both skin firmness and resilience ( 3, 4 )

Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation

JiangJYangBSunYJinJZhaoZChenS.Diagnostic value of Serum concentration of galectin-3 in patients with heart failure with preserved ejection fraction

(3) If symptoms were present, they included dark urine or pruritis early during the disease course