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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

Cox, Daniel Eichner Published: Drug Testing and Analysis, Volume 7, Issue 1, January 2015, pages 3138 DOI: 10.1002/dta.1715 URL: AOD9604 was incubated in human serum and rat plasma at room temperature to study in vitro metabolic degradation

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Additionally, variations in genes encoding glutathione synthesis enzymes (GCLC, GCLM) can reduce baseline GSH production, though these are less common