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For these experiments, the controls consisted of untreated aVICs and treatment with TGF- 1 (5 ng/mL), a known stimulus of myofibroblastic differentiation 39

While this effect is often considered beneficial in research contexts, it necessitates careful tracking to prevent too much glucose lowering, very in subjects with already normal insulin response

Isaacs says that while most people can safely take a GLP-1, you should avoid it if you have severe gastroparesis (stomach paralysis)