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Mechanism of Action Tesamorelin exerts its therapeutic effects through selective binding to and activation of the growth hormone-releasing hormone receptor (GHRHR), a G-protein coupled receptor expressed on somatotroph cells in the anterior pituitary gland

For skin, the primary mechanisms include stimulation of collagen I and III synthesis, increased production of decorin (which organizes collagen fibers), upregulation of VEGF for blood vessel formation, and activation of tissue remodeling through metalloproteinase regulation