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doi: 10.3389/fimmu.2025.1639196 Received 01 June 2025 Accepted 17 September 2025 Published 03 October 2025 Volume 16 - 2025 Edited by Haibo Dong, University of North Carolina at Greensboro, United States Reviewed by Dawit Tadese, Ethiopian Institute of Agricultural Research (EIAR), Ethiopia Ji Sun, China Medical University, China Xiaoliang Gao, Fourth Military Medical University, China Updates Copyright 2025 Wang, Duan, Zhao, Zhang, Yu and Zhao

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Though she was prescribed medication, she didn't make lifestyle changes a move she feels might have "very slowly made my condition worse." The neuroscientist was also diagnosed with Sjgren's syndrome, dysautonomia, connective tissue disease, and mast cell activation syndrome (MCAS) in later years, and suffered from extreme symptoms of the conditions, including "crippling depression" and "full-body rashes." Bialik shared that separate three doctors suggested she go on a GLP-1 drug "not because of the 20 postmenopausal pounds but because the drugs have shown promise in reducing the systemic inflammation that drives autoimmune conditions." "Maybe this could be the magic cure," she recalled of her mindset at the time