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NRF2 is an important regulator for maintaining intracellular redox homeostasis, upregulating the expression of various genes involved in iron and ROS metabolism (NQO1, HO1, and FTH1) through the p62-Keap1-NRF2 pathway and inhibiting cellular ferroptosis [62]

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This symptom typically arises through indirect mechanisms including hypoglycemia when combined with other diabetes medications, dehydration from gastrointestinal side effects, or orthostatic hypotension related to rapid weight loss

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