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Monitoring protocols should address both the primary indication (diabetes or weight management) and potential hepatic effects, particularly in patients with known or suspected NAFLD

A pH-responsive metal-organic framework for the co-delivery of HIF-2 siRNA and curcumin for enhanced therapy of osteoarthritis

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Key measurements include lipid peroxidation markers such as malondialdehyde and 4-hydroxynonenal, antioxidant defense markers such as GPX4 activity and the GSH/oxidized GSH ratio and advanced MRI-based assessments such as quantitative susceptibility mapping to quantify brain iron deposition (95,96)