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SA node effect shud be right from beginning, why sympathetic effect on SA shows after a lag at 24 weeks, also if it's as shown in graph peaks after hiatus is this due to drug induced Increased basal metabolic rate(obvioous will be increased HR)

These pre-clinical studies attributed the recovery in symptom profile to modulation of glucose transport, over-expression of mitochondrial genes, bypassing defective pathways of ETC (electron transport chain), and improvement in mitochondrial biosynthesis, modulation of microbiota, regulation of brain neuronal networks, and promoting synthesis of white matter in the brain [168]

Elbe says

This does not mean the compounded substance is itself FDA approved