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It helps to: Signal fullness to your brain Slow down how quickly food leaves your stomach Regulate blood sugar levels GLP-1 medications work by mimicking this natural hormone
As Phase 3 trials complete and a cardiovascular outcomes trial reports, we will have a much clearer picture
Pivotal Phase 2 Trial Results The pivotal Phase 2 trial, published by Jastreboff and colleagues in the New England Journal of Medicine in August 2023, enrolled 338 adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity but without diabetes
In sum, current evidence positions GLP-1 RAs as a potential cardioprotective strategy in HF, with HF with preserved ejection fraction emerging as the clinically most relevant phenotype for the drug class, especially when occurring in people with obesity with and without diabetes
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