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Furthermore, NOS3 knockout mice display increased infarct sizes compared to wild type mice post middle cerebral artery occlusion (MCAO) (Huang et al., 1996)

doi: 10.1038/ejcn.2014.46

However, its use is largely limited by acute kidney injury (AKI), which, if left untreated, may progress to cause irreversible chronic renal dysfunction

The inter-chain disulfide between heavy and light chains is not required for the Fab stability and is not present in our SpyTagged Fab fragments 5