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HFpEF patients included in these studies predominantly had LVEF 50%, aligning with guideline-defined HFpEF criteria

(trimrx.com) Why Sugar Spikes Matter In addition to the fat content, the high sugar levels in traditional ice cream can interact with how the medication regulates blood glucose

88,89 Under energy-deprived conditions, such as fasting, SIRT1 activity is upregulated, promoting fatty acid oxidation and ketogenesis via the PGC-1/PPAR axis, thereby improving hepatic metabolic adaptability

Retatrutide remains a developing therapy