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The following are the objectives of the study: Objective 1: To investigate whether treatment with semaglutide in women with PCOS and obesity will modulate microenvironment of the taste buds as assessed by transcriptomic profile (RNA-seq) Objective 2: To investigate whether treatment with semaglutide will enhance the sensitivity for sweet taste Objective 3: To investigate whether treatment with semaglutide will modulate neural response to visual food cues and to sweet-tasting substances in reward processing regions Objective 4: To investigate whether treatment with semaglutide will alter food preference Methods and analysis The SPIRIT reporting guidelines was used in the protocol [20]

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