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11,12 Mice lacking IGF-1R specifically in chondrocytes exhibit a shorter and narrower growth plate, and the size of individual hypertrophic chondrocytes appeared smaller compared to that of control littermates

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Research shows that 10-15% of patients don't respond adequately to semaglutide, but for most people experiencing plateaus, the issue is a diminished response rather than a true non-response, making strategic adjustments more effective than abandoning treatment entirely