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TMZ showed no significant difference (Figures 6AE)

Stopping tirzepatide may cause rebound weight gain as appetite and metabolic signals reset

Each works differently, and the best choice depends on your health goals and medical history

At the agent-level, several individual GLP-1RAs demonstrated moderate to high certainty for MACE when compared with placebo, whereas certainty for other outcomes was generally low to moderate, reflecting wider confidence intervals and greater between-study heterogeneity (Supplementary Table S26)