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The role of IECs in the coordination of immune pathways is largely dependent on their ability to express surface receptors, namely Toll-like receptors (TLRs), at their apical and basolateral membranes which are used to detect the presence of harmful stimuli (Abreu 2010

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The complementary mechanisms of amylin and GLP-1 pathways have generated significant scientific interest, with researchers exploring whether combined receptor activation produces synergistic improvements in weight and metabolic outcomes

More high-quality research is needed before DSIP can be recommended as a standard sleep treatment