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293 Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase in the TLR-mediated pathway, and inhibition of IRAK1/4 can block the TLR4/NF-B pathway and reduce intestinal inflammation

Furthermore, we demonstrated that RSL3 treatment impairs the phosphorylation of other downstream mTOR-related proteins, such as S6 and 4E-BP-1

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Reduced FH enzyme activity leads to the accumulation of the cellular level of fumarate, and fumarate can undergo a reaction with cysteine residues of proteins, which is called succination (Pollard et al., 2005)