joint pain semaglutide May Reverse Damage Caused by Osteoarthritis, Study Suggests : ScienceAlert Semaglutide beneficial for people with

Week 1-4: Starting dose (2.5mg) Weekly dose : 2.5mg Why this dose : Introduces GLP-1 effect Minimal side effects Tests tolerance Begins appetite suppression What to expect : Mild appetite reduction (20-30%) Slight nausea first few days (30% of users) Weight loss: 2-4 lbs (mostly water) Energy may dip initially Common mistake : Thinking 2.5mg is "too low" and skipping to 5mg

Specific clinical safety questions should go to a registered healthcare provider

Theoretical and Class-Level Risks These have not been confirmed in cagrilintide trials but are flagged because they appear in related amylin or GLP-1 class data: pancreatitis, gallbladder disease, severe hypoglycemia (mainly when combined with insulin or sulfonylureas), and acute kidney injury secondary to dehydration from severe nausea or vomiting

Adv Exp Med Biol 136, B86579