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In -thalassemia oxidative stress is induced by repeated blood transfusions, suppressed hepcidin, and subsequent iron overload, resulting in 8-oxodG mutagenic lesions on mtDNA

These results provide us confidence to initiate MARITIME, a Phase III program across obesity and a number of related conditions, providing a unique potential new treatment option for patients. MariTide was well-tolerated across all dosage groups, with the most common side effects being mild gastrointestinal symptoms, such as nausea and diarrhea, which were largely mild, transient and primarily associated with the first dose, according to Amgen

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Linagliptin isotope-labeled compounds enable precise tracking of the drug and its metabolites in biological systems, facilitating detailed understanding of its absorption, distribution, metabolism, and excretion (ADME)