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If the second or third doses are missed: If the fourth or subsequent doses are missed: Refer to Table 1 and Table 2 for dosage modifications for patients who are CYP2D6 poor metabolizers and/or in patients taking concomitant CYP3A4 inhibitors or CYP2D6 inhibitors for greater than 14 days

Bleeding disorders or anticoagulant therapy: The nitric oxide and vascular effects could theoretically interact with anticoagulant medications

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This staged method is often preferred because peptides usually dissolve more effectively in the correct initial solvent before being diluted