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In addition, GLP-1 can slow gastric emptying, reduce appetite in patients and thus reduce body mass, control blood pressure, regulate blood lipids and protect cardiovascular function, and has a low risk of hypoglycemia

Smaller, Frequent Meals: Users often suggest eating smaller portions more frequently throughout the day to minimize gastrointestinal strain

The clinical significance of the comparison is most relevant for patients who have already been on semaglutide or tirzepatide: for these patients, retatrutide offers a mechanistic step up rather than simply a higher dose of the same class