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The MicrobiotaPharmacokinetics (PK) Framework: As suggested by 7 Conclusion Synthesizing the evidence from 2015 to 2025, a high degree of consistency emerges between Traditional Chinese Medicine/natural product interventions for Rheumatoid Arthritis (RA) and the remodeling of gut microbiota structure and its functional output (metabolite profiles), phenomena that frequently parallel inflammation relief and improvement in joint pathology

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