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see third row)

5.4 Circadian regulation of autonomic nervous system (ANS) activity to attenuating BBB dysfunction of IS Sympathetic and parasympathetic activities exhibit circadian rhythmicity and modulate cerebrovascular function through neurovascular coupling mechanisms (152, 153).Sympathetic activity predominates during the daytime, whereas parasympathetic activity is enhanced at night (154)

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In both scenarios the key is consistent administration timing, tracking outcomes (sleep quality, restorative rest, stress resilience), and maintaining product/formulation integrity