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NO synthase (eNOS) phosphorylation Furthermore, exenatide reversed homocysteine-induced endothelial dysfunction by decreasing sICAM-1 and reactive oxygen species (ROS) levels and upregulating NO production and eNOS phosphorylation which further contributed the improvement of coronary endothelial function in diabetic patients [58]

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Recent research indicates that while GLP-1 medications significantly reduce body weight, fat-free mass lost accounts for 25-40% of the total weight lost during therapy, raising concerns about muscle loss