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However: Larger meta-analyses show no significant increase in risk after adjusting for confounders [25] Incidence appears similar to other diabetes therapies [25] Much of the observed signal likely reflects: Baseline risk (obesity, T2DM) Secondary gallstone disease In summary, pancreatitis in GLP-1 users is a rare and possible complication, but current evidence does not support a substantial increase in risk directly related to GLP-1 agents
Cysteamine is also used as a skin depigmenting agent in the treatment of various hyperpigmentation skin disorders (Hsu et al., 2013)
Available at: (Accessed on 24th December 2025).
The American Association for the Study of Liver Diseases notes that rapid weight loss of any cause increases gallstone risk, with rates as high as 30% in patients losing more than 1.5 kg per week [8]
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