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Both medications may cause serious side effects, including chest pain, swelling of the legs or ankles, irregular heartbeat, and mental or mood changes

In addition to advising patients to wait at least 30 min before taking other oral medications after oral semaglutide, increased clinical and laboratory monitoring should be considered when prescribing medications with a narrow therapeutic index or those that require clinical monitoring, such as levothyroxine [24, 75]

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