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When using hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, follow patients at frequent intervals and consider increasing the opioid dosage if needed to maintain adequate analgesia or if symptoms of opioid withdrawal occur (see PRECAUTIONS, Drug Interactions)
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It is of interest to note that FLNA splice variant-1, that was found widely expressed at low levels, lacks 41 amino acids between repeats 19 and 20, the region involved in the interaction both with DRD2 and SST2
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