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These findings suggest improved metabolic stability of FSEN1 in vivo (102)

Abbreviations ATP: Adenosinetriphosphate CADD: Computer aided drug design CDI: Carbonyldiimidazole DIPEA: N, N-diisopropylethylamine DMF: Dimethylformamide GDP: Guanosinediphosphate GN: Guanosine nucleotide GppNHp: Guanosine-5-[(,)-imido]triphosphate GST: Glutathione-S-transferase GTP: Guanosinetriphosphate KRAS: Kirsten rat sarcoma MD: Molecular dynamics MS: Mass spectrometry RBD: Ras binding domain SOS: Son of sevenless SWIIP: Switch-II-pocket References Scheffzek, K

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These include enhanced mitochondrial function, decreased inflammatory responses, and increased expression of cytoprotective proteins such as heat shock proteins