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These include abdominal distension, belching, and alternating constipation and diarrhea

Animal studies have shown increased bone formation and reduced bone resorption, suggesting potential benefits for conditions like osteoporosis

The standard escalation protocol is: Weeks 14 : 0.25 mg once weekly Weeks 58 : 0.5 mg once weekly Weeks 912 : 1 mg once weekly Weeks 1316 : 1.7 mg once weekly Week 17 onwards : 2.4 mg once weekly (maintenance dose) Patients who experience persistent hunger during the early titration phases should understand that appetite suppression typically increases with higher doses

The La Roche-Posay oncology programme demonstrates the model