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As primary care clinicians, we are in the ideal place to offer such support, as well as to share the benefits of orforglipron once it is licensed in the UK.

Selection criteria for the eta-analysis Inclusion criteria were studies (1) including healthy participants, (2) utilising 1 H-MRS to measure GSH levels in specified brain regions, (3) giving mean and SD for each group, (4) patients with depression only and not bipolar affective disorder in accordance with criteria specified in the Diagnostic and Statistical Manual for Mental Disorders (DSM) or the International Classification of Diseases (ICD-11), (5) information provided on sex of patients

Group membership had a significant impact on SOD and CAT activity ( p 30) (Fig

Many patients may, therefore, be at risk of adverse effects and uncertain long-term outcomes